Pancreatitis is a condition wherein the pancreas becomes
inflamed. Amongst the two forms of pancreatitis: acute and chronic, the latter
one constitutes long lasting inflammation. Major cause of chronic pancreatitis
is damage to pancreas due to heavy alcohol consumption. Hereditary disorders of
the pancreas, gall stones, high triglycerides, cystic fibrosis and certain
medications are the various other causes responsible for chronic pancreatitis.
Children are rarely known to be affected by chronic pancreatitis, but
incidences may occur in case of genetic mutations or trauma to the pancreas
though the cause is not completely known. Various tests are available to
diagnose chronic pancreatitis which include pancreatic function test, pancreas
exocrine function test, CT scans, abdominal ultrasound examination, magnetic
resonance cholangiopancreatography (MRCP), endoscopic ultrasound, genetic
testing and endoscopic retrograde cholangiopancreatography (ERCP).
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Constant pain in the upper abdomen radiating to the back is
the most common symptom associated with chronic pancreatitis. Other symptoms
are nausea, vomiting, weight loss due to malabsorption of food, steatorrhea and
diabetes if the insulin producing cells are damaged. Two major reasons
contributing to the pain in chronic pancreatitis are increased pressure in the
pancreatic ducts and inflammation of pancreatic nerve. Inflammation of pancreas
causes narrowing of the pancreatic duct, thus causing blockage. This leads to
building up of pancreatic secretions in the pancreatic duct, consequently
leading to pain.
The global chronic pancreatitis pain market can be segmented
based on therapy type, and geography. Therapies used to treat chronic
pancreatitis pain include medical therapy, endoscopic therapy and surgery. Medical
therapy is the first line of treatment in chronic pain management and may be
further classified as nonspecific supportive therapy, pancreatic enzymes,
octreotide, and antioxidant therapy. Analgesic drugs are the most commonly used
method to treat the concurrent symptoms as a supportive therapy. In some cases,
antidepressants and anti inflammatory drugs are also used as a concomitant
therapy. The use of oral pancreatic enzymes has been variable. These enzymes
replace the normally produced pancreatic enzymes; however, these enzymes are
not known to be effective in all people. Octreotide are
cholecystokinin-receptor antagonists that inhibit pancreatic secretion and thus
is known to be effective in reducing the chronic pain.
Endoscopic therapy is used to overcome pancreatic duct
obstruction caused due to strictures, stones or ampullary stenosis, though
endoscopic treatments are more used to prevent acute relapsing of pancreatitis.
Currently, endoscopic insertion of stents is known to have potential use in
chronic pancreatitis. Various pain modifying agents such as gabapentin,
antidepressants, and pregabalin, antioxidants, celiac plexus block, octreotide
and total pancreatectomy with islet cell auto transplantation are currently
undergoing extensive research. Nerve block involves injecting directly
into the nerves responsible for transmitting pain signals from the pancreas.
Pancreatic lithotripsy is the procedure used to break up stones lodged in the
pancreatic duct. This helps to improve the flow of digestive juices. Surgery is
recommended only when the individual does not respond to other treatments.
These surgical procedures include pancreaticojejunostomy to remove blockage and
pressure in the pancreatic duct, removal of part of the pancreas and an experimental
treatment known as autologous islet transplantation.
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Geographically, the chronic pancreatitis pain market can be
categorized into four major regions namely North America, Europe, Asia Pacific
and Rest of the World. Some of the key players contributing to the global
chronic pancreatitis pain market are Abbott, Aptalis Pharma, Inc., McNeil
Consumer Healthcare and Sun Biopharma while various institutions involved in
the research for treating chronic pancreatitis pain include Radboud University,
University Medicine Greifswald, and University of Albama.
This research report analyzes this market on the basis of its
market segments, major geographies, and current market trends. Geographies
analyzed under this research report include
- North America
- Asia Pacific
- Europe
- Rest of the World
This report provides comprehensive analysis of
- Market growth drivers
- Factors limiting market growth
- Current market trends
- Market structure
- Market projections for upcoming years
This report is a complete study of current trends in the
market, industry growth drivers, and restraints. It provides market projections
for the coming years. It includes analysis of recent developments in
technology, Porter’s five force model analysis and detailed profiles of top
industry players. The report also includes a review of micro and macro factors
essential for the existing market players and new entrants along with detailed
value chain analysis.
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