Mammalian target of rapamycin (mTOR)
is a protein that regulates vital cell growth processes in a living organism.
mTOR acts as a communication command centre in human body by receiving external
signals from growth factors, hormones, proteins and transfer the signal to on\'
or \'off\' mode for the cell to grow and divide. mTOR is considered as a member
of the phosphatidylinositol 3-kinase (PI3K) cell survival pathway which plays
an important role in the regulation of cell growth and proliferation. Akt
proteins can be able to activate mTOR, which promotes cell growth and
proliferation by stimulating protein synthesis. mTOR comprises two distinct
multi protein complexes that includes mTOR complex 1 and mTOR complex 2. mTOR
protein plays an important role in the regulation of various cancer cell such
as breast cancer, colon cancer, ovarian cancer and cervical cancer.
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Many human cancer causes due to
dysregulation of mTOR signaling and can confer higher susceptibility to mTOR
inhibitors. Disregulation of mTOR signaling includes PI3K
amplification/mutation, Phosphatase and Tensin Homolog (PTEN) loss of function,
eIF4E protein over expression and over expression of protein kinase B. Thus,
rising prevalence of various cancers (lung cancer, prostate cancer, breast
cancer and cervical cancer) the global market for mTOR inhibitors is
experiencing a significant growth worldwide. For instance, the World Health
Organization (WHO) published in 2014, that worldwide 8.2 million people died of
cancer in the year 2012. In 2013, American Cancer Society (ACS) published that,
around 300,000 men and 276,000 women died due to cancer in 2012 in the U.S.
California Journal of Clinical Cancer (CJCC) stated that, one in the every six
U.S. men have received diagnosis test for prostate cancer at some point in
their lives.
It has also stated that in 2010,
217,730 men were diagnosed with prostate cancer in the U.S. Moreover, National
Centre for Biotechnology Information (NCBI) stated that, prevalence of prostate
cancer is more in geriatric people (above 65 years of age). Thus, growing
geriatric population also fuels the global market demand of mTOR inhibitors.
However, high cost and technical complexity associated with the diagnosis
procedure (detection) of mTOR would hinder the global market demand during the
study period.
North America and Europe was
observed to be the largest mTOR inhibitors market due to major market players
are based in these regions. Moreover, North America and Europe accounted for
the highest number of diagnosis cases performed with respect to various cancer
(lung cancer, prostate cancer, breast cancer and cervical cancer) every year.
In addition, favorable initiatives taken by the federal government also
accounted for the mTOR inhibitors market growth in North American and European
regions. Similarly, Asia-Pacific is considered as an untapped market due to
lack of proper healthcare facilities in some Asian countries.
Asian market growth will be fuelled
by the presence of untapped opportunities due to extensive increase in the
healthcare infrastructure (healthcare cost, healthcare facility and healthcare
budget). Similarly, Asia-Pacific is considered as an emerging market due to
growing market penetration in this region. Rest of the World (RoW) holds fourth
position in the global mTOR inhibitors market due to poor economic and health
condition in most of the African countries.
Various key players contributing the
global market share of mTOR inhibitors market include LC Laboratories, UniProt,
Biotool, Exelixis, Inc., Novartis AG, Enzymlogic, BioLegend, Inc., Enzo
Biochem, Cell Signaling Technology, Inc., Fluofarma among others.
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This research report analyzes this
market depending on its market segments, major geographies, and current market
trends. Geographies analyzed under this research report include
- North America
- Asia Pacific
- Europe
- Rest of the World
This report provides comprehensive
analysis of
- Market growth drivers
- Factors limiting market growth
- Current market trends
- Market structure
- Market projections for upcoming years
This report is a complete study of
current trends in the market, industry growth drivers, and restraints. It
provides market projections for the coming years. It includes analysis of
recent developments in technology, Porter’s five force model analysis and
detailed profiles of top industry players. The report also includes a review of
micro and macro factors essential for the existing market players and new
entrants along with detailed value chain analysis.
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